"New Insights into Systemic Sclerosis" ed. by Michal Tomcik

This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.

Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date.


Contents
1.Advances in Management of Pulmonary Hypertension Associated with Systemic Sclerosis
2.Renal Involvement in Systemic Sclerosis
3.Gastrointestinal Involvement in Systemic Sclerosis: Overview, Neglected Aspects, Malnutrition, Body Composition and Management
4.Systemic Sclerosis Mimics
5.Sexual Dysfunction in Patients with Systemic Sclerosis
5.1.Corrigendum to: Sexual Dysfunction in Patients with Systemic Sclerosis
6.Biopsychosocial Aspects in Management of Scleroderma Patients